Thilo Krüger

Former Member

Associate Researcher

Modeling and Simulation Group, Saarland University

thilo.krueger@uni-saarland.de

About Me

Research Project

In simulating biological systems stochastically, one modern approach to manage the big number of states and interactions is the so-called Rule-Based Modeling. Here, the individual species are not explicitely considered in computing the possible reactions. Instead the possible reactions are seen as rules, and the species, which are affected by the selected rule are chosen by random. In technichal polymerization reactions the numbers of states and interactions are even bigger. The aim of my research is, to convey the concept of Rule-Based Modeling to such reactions.

Publications

T. Krüger, V. Wolf: Hybrid Stochastic Simulation of Rule-Based Polymerization Models. HSB 2016: 39-53 2015
C. Bock, L. Bortolussi, T. Krüger, L. Mikeev, V. Wolf: Model-Based Whole-Genome Analysis of DNA Methylation Fidelity. HSB 2015: 141-155
L. Bortolussi, T. Krüger, T. Lehr, V. Wolf: Rule-based modelling and simulation of drug-administration policies. SpringSim (MSM) 2015: 53-60
A. Andreychenko, T. Krüger, D. Spieler: Analyzing Oscillatory Behavior with Formal Methods. ROCKS 2012: 1-25

Interests

Rule-Based Modeling
Stochastic Modeling of Polymerization Reactions
Polymer Reaction Engineering

Publications (3)

2016

1 paper

Hybrid Stochastic Simulation of Rule-Based Polymerization Models

Thilo Krüger and Verena Wolf

2016 — Hybrid Systems Biology - 5th International Workshop, Proceedings. International Conference on Hybrid Systems Biology (HSB-2016), October 20-21, Grenoble, France

@inproceedings{krugerHybridStochasticSimulationOf2016,
 author = {Thilo Krüger and Verena Wolf},
 booktitle = {Hybrid Systems Biology - 5th International Workshop, Proceedings. International Conference on Hybrid Systems Biology (HSB-2016), October 20-21, Grenoble, France},
 doi = {10.1007/978-3-319-47151-8_3},
 editor = {Eugenio Cinquemani and Alexandre Donzé},
 isbn = {9783319471518},
 month = {9},
 pages = {39-53},
 publisher = {Springer International Publishing},
 series = {Lecture Notes in Computer Science, LNCS},
 title = {Hybrid Stochastic Simulation of Rule-Based Polymerization Models},
 volume = {9957},
 year = {2016}
}

2015

2 papers

Model-Based Whole-Genome Analysis of DNA Methylation Fidelity

Christoph Bock, Luca Bortolussi, Thilo Krüger, Linar Mikeev and Verena Wolf

2015 — Hybrid Systems Biology - Fourth International Workshop. Revised Selected Papers. International Conference on Hybrid Systems Biology (HSB-2015), September 4-5, Madrid, Spain

@inproceedings{bockModelBasedWholeGenomeAnalysisOf2015,
 author = {Christoph Bock and Luca Bortolussi and Thilo Krüger and Linar Mikeev and Verena Wolf},
 booktitle = {Hybrid Systems Biology - Fourth International Workshop. Revised Selected Papers. International Conference on Hybrid Systems Biology (HSB-2015), September 4-5, Madrid, Spain},
 doi = {10.1007/978-3-319-26916-0_8},
 editor = {Alessandro Abate and David Šafránek},
 isbn = {9783319269160},
 month = {9},
 pages = {141-155},
 publisher = {Springer International Publishing, Switzerland},
 series = {Lecture Notes in Computer Science, LNCS},
 title = {Model-Based Whole-Genome Analysis of DNA Methylation Fidelity},
 volume = {9271},
 year = {2015}
}

Rule-based modelling and simulation of drug-administration policies

Luca Bortolussi, Thilo Krüger, Thorsten Lehr and Verena Wolf

2015 — MSM ‘15: Proceedings of the Symposium on Modeling and Simulation in Medicine

@incollection{bortolussiRuleBasedModellingAndSimulation2015,
 author = {Luca Bortolussi and Thilo Krüger and Thorsten Lehr and Verena Wolf},
 booktitle = {MSM '15: Proceedings of the Symposium on Modeling and Simulation in Medicine},
 editor = {Nicht bekannt},
 isbn = {978-1-5108-0102-8},
 month = {4},
 pages = {53-60},
 publisher = {ACM},
 title = {Rule-based modelling and simulation of drug-administration policies},
 year = {2015}
}