A Hybrid HMM Approach for the Dynamics of DNA Methylation

Abstract

The understanding of mechanisms that control epigenetic changes is an important research area in modern functional biology. Epigenetic modifications such as DNA methylation are in general very stable over many cell divisions. DNA methylation can however be subject to specific and fast changes over a short time scale even in non-dividing (i.e. not-replicating) cells. Such dynamic DNA methylation changes are caused by a combination of active demethylation and de novo methylation processes which have not been investigated in integrated models.

@inproceedings{kyriakopoulosAHybridHMMApproach2019,
 address = {Cham},
 author = {Kyriakopoulos, Charalampos and Giehr, Pascal and Lück, Alexander and Walter, Jörn and Wolf, Verena},
 booktitle = {Hybrid Systems Biology},
 editor = {Češka, Milan and Paoletti, Nicola},
 isbn = {978-3-030-28042-0},
 pages = {117--131},
 publisher = {Springer International Publishing},
 title = {A Hybrid HMM Approach for the Dynamics of DNA Methylation},
 year = {2019}
}