DNA Methylation
DNA methylation is an epigenetic mark whose important role in development has been widely recognized. This epigenetic modification …
@article{luckHiddenMarkovModellingReveals2019,
author = {Alexander Lück and Pascal Giehr and Karl Nordström and Jörn Walter and Verena Wolf},
doi = {10.1109/TCBB.2019.2910814},
journal = {IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)},
month = {4},
number = {5},
pages = {1598-1609},
publisher = {IEEE},
title = {Hidden Markov Modelling Reveals Neighborhood Dependence of Dnmt3a and 3b Activity},
volume = {16},
year = {2019}
}
DNA methylation and demethylation are opposing processes that when in balance create stable patterns of epigenetic memory. The control …
@article{giehrTheInfluenceOfHydroxylation2016,
author = {Pascal Giehr and Charalampos Kyriakopoulos and Gabriella Ficz and Verena Wolf and Jörn Walter},
doi = {10.1371/journal.pcbi.1004905},
journal = {PLOS Computational Biology},
month = {5},
number = {5},
pages = {1-16},
publisher = {Public Library of Science},
title = {The Influence of Hydroxylation on Maintaining CpG Methylation Patterns: A Hidden Markov Model Approach},
volume = {12},
year = {2016}
}
Summary Mouse embryonic stem cells are dynamic and heterogeneous. For example, rare cells cycle through a state characterized by …
@article{eckersleymaslinMERVLZscan4NetworkActivationResults2016,
author = {Mélanie A. Eckersley-Maslin and Valentine Svensson and Christel Krueger and Thomas M. Stubbs and Pascal Giehr and Felix Krueger and Ricardo J. Miragaia and Charalampos Kyriakopoulos and Rebecca V. Berrens and Inês Milagre and Jörn Walter and Sarah A. Teichmann and Wolf Reik},
doi = {10.1016/j.celrep.2016.08.087},
issn = {2211-1247},
journal = {Cell Reports},
number = {1},
pages = {179-192},
title = {MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs},
url = {https://www.sciencedirect.com/science/article/pii/S2211124716311962},
volume = {17},
year = {2016}
}
We consider the problem of understanding how DNA methylation fidelity, i.e. the preservation of methylated sites in the genome, varies …
@inproceedings{bockModelBasedWholeGenomeAnalysisOf2015,
author = {Christoph Bock and Luca Bortolussi and Thilo Krüger and Linar Mikeev and Verena Wolf},
booktitle = {Hybrid Systems Biology - Fourth International Workshop. Revised Selected Papers. International Conference on Hybrid Systems Biology (HSB-2015), September 4-5, Madrid, Spain},
doi = {10.1007/978-3-319-26916-0_8},
editor = {Alessandro Abate and David Šafránek},
isbn = {9783319269160},
month = {9},
pages = {141-155},
publisher = {Springer International Publishing, Switzerland},
series = {Lecture Notes in Computer Science, LNCS},
title = {Model-Based Whole-Genome Analysis of DNA Methylation Fidelity},
volume = {9271},
year = {2015}
}
The enzymatic control of the setting and maintenance of symmetric and non-symmetric DNA methylation patterns in a particular genome …
@article{arandInVivoControlOf2012,
author = {Julia Arand and David Spieler and Tommy Karius and Miguel R. Branco and Daniela Meilinger and Alexander Meissner and Thomas Jenuwein and Guoliang Xu and Heinrich Leonhardt and Verena Wolf and Jörn Walter},
doi = {10.1371/journal.pgen.1002750},
journal = {PLOS Genetics},
month = {6},
number = {6},
pages = {1-11},
publisher = {PLOS},
title = {In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases},
url = {https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002750},
volume = {8},
year = {2012}
}